Trimetazidine Dihydrochloride

Trimetazidine Dihydrochloride is a antianginal metabolic agent medicine available in Bangladesh under many brand names. Below are its uses, dosage, side effects and precautions — and all brands with their current prices.

• Adjunctive symptomatic treatment of stable angina pectoris in adults who are inadequately controlled by, or intolerant to, first-line anti-anginal therapy.
• It is not indicated for immediate relief of acute angina attacks and is not a treatment for myocardial infarction.

Adults should take Trimetazidine Dihydrochloride exactly as prescribed by the doctor. The dose and frequency depend on the tablet strength or formulation, kidney function, age, and other medicines being used; it is commonly taken regularly with meals. Do not change the dose or stop treatment without medical advice. For sudden or severe chest pain, use the emergency medicine and action plan advised by the doctor and seek urgent care if symptoms persist.

• Common side effects may include dizziness, headache, abdominal pain, indigestion, nausea, vomiting, diarrhoea, rash, itching, hives, and weakness.
• Uncommon or serious effects can include palpitations, fast heartbeat, low blood pressure or dizziness on standing, flushing, and falls.
• Rare but important effects include Parkinson-like symptoms such as tremor, slowed movement, muscle stiffness, restless legs, unsteady walking, or other movement problems; these usually require stopping the medicine after medical review.
• Very rare serious reactions such as severe skin allergy, low platelet or white blood cell counts, or liver inflammation have been reported; seek medical help if there is unusual bleeding, fever, jaundice, or severe rash.

Use caution in older adults, people with kidney impairment, people at risk of falls, and anyone with current or past movement disorders such as Parkinson's disease, tremor, restless legs syndrome, or gait instability. Report any new shaking, stiffness, slow movement, or walking difficulty promptly. This medicine should not be used to treat sudden chest pain. Use Trimetazidine Dihydrochloride under the guidance of a registered doctor or pharmacist.

• No major, consistently proven drug interactions are well established, but patients should tell the doctor or pharmacist about all prescription medicines, over-the-counter medicines, and herbal products they use.
• It should be used as add-on therapy and should not replace prescribed emergency angina medicines such as short-acting nitrates, or other heart medicines unless the doctor advises.
• Alcohol may worsen dizziness or light-headedness in some people; avoid or limit alcohol if affected.
• Taking the tablet with meals may help reduce stomach upset and is commonly advised for many formulations.

• Known hypersensitivity to trimetazidine or any tablet ingredient.
• Parkinson's disease, Parkinsonian symptoms, tremor, restless legs syndrome, or other related movement disorders.
• Severe kidney impairment, commonly defined as creatinine clearance below 30 mL/min.

There is limited human safety information for Trimetazidine Dihydrochloride in pregnancy, so it is generally avoided unless a doctor decides the potential benefit justifies the risk. It is not known whether trimetazidine passes into breast milk; breastfeeding mothers should use it only after medical advice, and an alternative may be preferred.

Store tablets in the original packaging at room temperature, away from excess heat, moisture, and direct sunlight. Keep out of the reach of children and do not use after the expiry date.