Nicotinamide + Pyridoxine Hydrochloride + Riboflavin + Vitamin B1

Nicotinamide + Pyridoxine Hydrochloride + Riboflavin + Vitamin B1 is a vitamin B-complex supplement medicine. It is available in Bangladesh under many brand names. Below are its uses, side effects and precautions, and every brand with its current price.

• Prevention and treatment of deficiency of thiamine, riboflavin, niacin/nicotinamide or pyridoxine.
• Supplementation when dietary intake is inadequate or requirements are increased, as assessed by a healthcare professional.
• Supportive use in conditions associated with B-vitamin deficiency symptoms such as glossitis, angular stomatitis, dermatitis or nutritional neuropathy, when deficiency is suspected or confirmed.

• Usually well tolerated at recommended doses.
• Possible mild nausea, stomach upset, diarrhoea or headache.
• Riboflavin may cause bright yellow urine; this is harmless.
• Allergic reactions such as rash, itching, swelling or breathing difficulty are rare but require urgent medical help.
• Long-term high-dose pyridoxine may cause nerve problems such as numbness, tingling or difficulty walking.
• High doses of nicotinamide may rarely affect the liver or blood sugar, especially in susceptible people.

People with liver disease, kidney disease, diabetes, gout, peptic ulcer disease, unexplained nerve symptoms, or those already taking other vitamin supplements should seek medical advice before use. Do not use this supplement to treat persistent weakness, mouth ulcers, skin problems or neuropathy without checking for the underlying cause. Use under the guidance of a registered doctor or pharmacist.

• Pyridoxine can reduce the effect of levodopa when levodopa is used without carbidopa or benserazide.
• Isoniazid, cycloserine, hydralazine, penicillamine and some other medicines may increase the need for pyridoxine; dosing should be guided by a clinician.
• Alcohol misuse can worsen thiamine and other B-vitamin deficiency and may reduce the benefit of supplementation.
• Loop diuretics such as furosemide may increase thiamine loss in urine with long-term use.
• Taking several multivitamins or fortified products together may increase the risk of excessive vitamin intake.

• Known hypersensitivity or previous serious allergic reaction to nicotinamide, pyridoxine, riboflavin, thiamine or any excipient in the product.
• Do not use high-dose preparations without medical supervision in people who have had toxicity or intolerance to any of these vitamins.

These B vitamins are essential nutrients and are generally considered safe in pregnancy and breastfeeding when used at recommended nutritional doses. Pregnant or breastfeeding women should avoid high-dose or multiple vitamin preparations unless prescribed, because individual needs and total intake from diet and other supplements must be considered.

Store at room temperature, away from excessive heat, moisture and direct sunlight. Keep the container tightly closed and out of the reach of children. Do not use after the expiry date or if the product changes colour, smell or appearance.