Cyanocobalamin + Pyridoxine Hydrochloride + Vitamin B1

Cyanocobalamin + Pyridoxine Hydrochloride + Vitamin B1 is a vitamin b-complex supplement medicine available in Bangladesh under many brand names. Below are its uses, dosage, side effects and precautions — and all brands with their current prices.

• Prevention and treatment of vitamin B1, B6, and B12 deficiency.
• Supportive treatment of peripheral neuritis or neuropathic symptoms associated with deficiency of these vitamins.
• Vitamin B12 replacement in deficiency states, including megaloblastic anemia due to vitamin B12 deficiency, when this combination is considered appropriate by a doctor.
• Increased vitamin B requirement in selected patients as advised by a healthcare professional.

Adult dosage depends on the dosage form, severity of deficiency, symptoms, diet, and medical condition. Tablets are usually taken by mouth as directed, while injections should be given only by trained healthcare personnel and only when prescribed. Follow the doctor’s exact dose, route, and duration; do not continue high-dose vitamin B6 for long periods without medical supervision.

• Common: nausea, stomach upset, diarrhea, headache, flushing, or unusual taste.
• Injection-related: pain, redness, swelling, or irritation at the injection site.
• Skin reactions: rash, itching, or acne-like eruptions may occur in some people.
• Serious but uncommon: allergic reaction, wheezing, facial or throat swelling, severe dizziness, or anaphylaxis, especially with injections.
• Rare: low potassium during early treatment of severe vitamin B12 deficiency, or worsening numbness/tingling with excessive long-term pyridoxine use.

Use with caution in people with a history of allergy to vitamin preparations, cobalt sensitivity, Leber’s hereditary optic neuropathy, unexplained anemia, kidney disease, or persistent neurological symptoms. Vitamin treatment can mask important diagnoses if anemia or nerve symptoms are not properly investigated. Use under a registered doctor’s or pharmacist’s guidance, especially for injections, pregnancy, breastfeeding, children, older adults, or long-term use.

• Levodopa: pyridoxine may reduce the effect of levodopa when levodopa is used without carbidopa or benserazide.
• Isoniazid, cycloserine, penicillamine, and hydralazine: may increase pyridoxine requirement or interact with vitamin B6 metabolism.
• Metformin, proton pump inhibitors, and H2 blockers: long-term use may reduce vitamin B12 absorption.
• Chloramphenicol: may reduce the blood response to vitamin B12 in some patients.
• Alcohol: can worsen thiamine deficiency and reduce nutritional status.
• Loop diuretics such as furosemide: long-term use may increase thiamine loss.

• Known hypersensitivity to cyanocobalamin, pyridoxine, thiamine, cobalt, or any component of the product.
• Leber’s hereditary optic neuropathy, unless a specialist decides otherwise.
• Do not use injections without a prescription or when the product has particles, discoloration, or damaged packaging.

Vitamin B1, B6, and B12 are required during pregnancy and breastfeeding, and usual recommended intake is generally considered safe. However, high-dose supplements or injections should be used only when clearly needed and prescribed by a healthcare professional. Breastfeeding mothers should avoid prolonged high-dose pyridoxine unless advised by a doctor.

Store at room temperature, away from excessive heat, moisture, and direct light. Keep tablets in the original container and injections protected as instructed on the label. Keep all medicines out of reach of children and do not use after the expiry date.