ChamberBD Logo ChamberBD

Capsule

Flubex 250 mg Capsule

Generic: Flucloxacillin

Manufacturer: Beximco Pharmaceuticals Ltd.

Therapeutic class: Penicillinase-resistant penicillin antibiotic

What is Flubex?

Flubex 250 mg capsule by Beximco Pharmaceuticals Ltd. contains Flucloxacillin, a penicillin-type antibiotic that is especially effective against staphylococcus ("staph") bacteria. It is mainly used for skin and soft-tissue infections such as cellulitis, infected wounds, boils, and abscesses, as well as some bone, ear, and chest infections. Flubex is a prescription-only medicine and must be taken exactly as a registered doctor instructs.

Flucloxacillin works by breaking down the protective cell wall that bacteria build to survive. Unlike ordinary penicillin, it resists an enzyme (penicillinase) that staph bacteria use to defend themselves, so it can kill these otherwise resistant bacteria. It acts only against bacteria and has no effect on viral illnesses.

Indications

  • Skin and soft-tissue infections (cellulitis, boils, abscesses)
  • Infected wounds, burns, and insect bites
  • Impetigo and other staph skin infections
  • Bone and joint infections (often with other treatment)
  • Some ear, chest, and surgical-wound infections

Dosage & Administration

The dose of Flubex depends on the infection. A common adult dose is 250-500 mg four times a day for about 7 days, sometimes longer for bone or deep infections as the doctor decides. Take Flubex on an empty stomach — at least 1 hour before, or 2 hours after, food — with a full glass of water, because food reduces its absorption.

Children's doses are based on body weight and must be set by a doctor. Space the four daily doses evenly, complete the whole course, and do not stop once the skin or wound starts to look better.

Side Effects

Flucloxacillin is usually well tolerated. Possible side effects include:

  • Nausea, vomiting, or diarrhoea
  • Indigestion or abdominal discomfort
  • Mild skin rash
  • Thrush with longer courses

Rarely, flucloxacillin can cause liver problems (sometimes appearing days or weeks after stopping) with yellowing of the skin or eyes, dark urine, and itching. Seek urgent care for serious allergic reactions, jaundice, or severe, persistent diarrhoea.

Precautions & Warnings

Flubex is a prescription-only antibiotic — never self-medicate. Take it only when a registered doctor prescribes it, and never share it with others or buy it over the counter for a skin problem. Always complete the full course, even after the wound or rash looks healed; the infection can reach deeper than it appears, and stopping early lets resistant bacteria survive and return.

Tell your doctor about any penicillin allergy or past liver problems with this medicine. Antibiotic resistance is a serious national crisis in Bangladesh, and using antibiotics like Flucloxacillin without proper advice or for the wrong reasons makes it worse.

Drug Interactions

Tell your doctor about all medicines you take. Notable interactions with Flucloxacillin include:

  • Methotrexate — its toxicity can increase
  • Probenecid — raises flucloxacillin levels in the blood
  • Warfarin — bleeding tendency may change
  • Paracetamol — taken together in high doses long term, a rare blood-acid problem has been reported
  • Oral typhoid vaccine may be less effective

Contraindications

Do not take Flubex if you:

  • Are allergic to flucloxacillin, penicillin, or related antibiotics
  • Have had jaundice or liver problems caused by flucloxacillin before

Use with caution and tell your doctor if you have liver or kidney disease, or are elderly, as the rare risk of liver effects is higher. Your doctor will decide whether Flubex is suitable for you.

Pregnancy & Lactation

Flucloxacillin is generally considered acceptable during pregnancy when needed, as penicillins have a long record of use, but take it only on a doctor's advice. Tell your doctor if you are pregnant or planning to conceive.

Only tiny amounts pass into breast milk and it is usually regarded as compatible with breastfeeding, though the baby may occasionally have loose stools or thrush. Always mention breastfeeding before starting Flubex.

Storage Conditions

Store Flubex in a cool, dry place below 30°C, away from direct sunlight and moisture, in its original pack. Reconstituted suspension for children should be kept as advised on the label (often refrigerated) and used within the stated time. Keep all forms out of children's reach and do not use after the expiry date.

Frequently Asked Questions

Why must I take Flubex on an empty stomach?

Food in the stomach greatly reduces how much flucloxacillin is absorbed, so Flubex works best when taken on an empty stomach — at least 1 hour before a meal or 2 hours after. Swallow it with a full glass of water. Taking it with food may leave too little medicine in the blood to clear the infection properly. Try to set regular times, for example before breakfast, lunch, dinner, and bedtime, to keep all four daily doses evenly spaced and on an empty stomach.

My skin infection looks healed — can I stop Flubex now?

No. A wound or rash often looks better on the surface while bacteria are still present in the deeper tissue. If you stop Flubex early, these survivors can multiply, the infection can flare up again or spread, and the bacteria can become resistant — making the next infection much harder to treat. Always finish every dose for the full number of days your doctor prescribed. Antibiotic resistance is a serious national crisis in Bangladesh, and completing your course exactly as directed helps protect you and others.

I am allergic to penicillin — is Flubex safe for me?

No. Flucloxacillin is itself a type of penicillin, so if you are allergic to penicillin you should not take Flubex. Tell your doctor about any past reaction to penicillin or other antibiotics — such as rash, swelling, or breathing difficulty — before you are prescribed anything. Your doctor can then choose a different, suitable antibiotic for your infection. A severe penicillin allergy can be life-threatening, so always keep it clearly noted on your medical records.

Was this information helpful?

Last updated: