Paridon 10 mg Tablet

Paridon 10 mg Tablet contains domperidone, a dopamine-antagonist medicine used as an antiemetic and prokinetic. It is prescribed to relieve nausea and vomiting and to help stomach contents move forward when gastric emptying is slow.

Paridon 10 mg tablet is a Domperidone preparation from Drug International Ltd., Gopalpur. It is an antiemetic and prokinetic medicine widely prescribed in Bangladesh for nausea and vomiting, and for symptoms of slow stomach emptying such as fullness after small meals, bloating, belching and upper abdominal discomfort. It is intended for short-term, doctor-guided use at the lowest effective dose.

Domperidone works by blocking dopamine D2 receptors. In the gut wall, this strengthens stomach contractions and coordinates movement between the stomach and the upper intestine, so food empties forward more efficiently. It also blocks dopamine in the brain's chemoreceptor trigger zone, which lies outside the main blood-brain barrier, calming the vomiting reflex with little drowsiness.

• Nausea and vomiting in adults and, per doctor, in children
• Functional dyspepsia with early fullness, bloating and belching
• Gastroparesis (delayed stomach emptying), including diabetic gastroparesis
• Reflux symptoms when slow gastric emptying contributes, as judged by a doctor
• Nausea associated with some medicines, for example during migraine, when prescribed

ChamberBD shows dosing only from the approved product label, with its source named, and no label is on file for Paridon 10 mg Tablet. Use the dose your doctor prescribed and the instructions in the pack leaflet.

Domperidone is usually well tolerated at recommended doses. Common side effects include dry mouth, headache, abdominal cramps and diarrhoea. Because it raises the hormone prolactin, some users notice breast tenderness, milk secretion or menstrual irregularity; these settle after stopping the medicine.

Rare but important effects involve the heart: domperidone can prolong the QT interval and, at high doses, in older patients or with interacting medicines, may trigger serious rhythm disturbance. Movement-related side effects such as muscle spasms or restlessness are rare, occurring mainly in children. Seek urgent care for palpitations, fainting, seizure-like episodes or severe allergic reactions.

Use domperidone cautiously and only under medical advice if you are over 60, have any heart disease, a history of rhythm problems or congenital long QT, or abnormal blood potassium or magnesium levels, as these increase the risk of serious arrhythmia. Tell your doctor about kidney or liver problems; doses may need reduction in kidney impairment.

Keep treatment short — typically up to one week unless your doctor specifically advises longer — and never combine it with other QT-prolonging medicines or strong CYP3A4 inhibitors. If vomiting persists, recurs or comes with severe pain, blood, drowsiness or dehydration, stop self-managing and get medical assessment promptly.

Do not take domperidone with medicines that prolong the QT interval or raise its blood level. Important examples include the antifungals ketoconazole, itraconazole, fluconazole and voriconazole; macrolide antibiotics such as erythromycin and clarithromycin; some antiarrhythmics (amiodarone); certain antipsychotics and antidepressants; and HIV protease inhibitors.

Grapefruit juice can also raise domperidone levels and is best avoided. Anticholinergic medicines may blunt its prokinetic effect, and it can alter the absorption of some other drugs by speeding stomach emptying. Always tell your doctor and pharmacist about every medicine, supplement and herbal product you use before starting domperidone.

Domperidone is contraindicated in people with known allergy to it, in moderate or severe liver impairment, and in anyone with existing QT prolongation, significant electrolyte disturbance or heart disease such as heart failure. It must not be combined with QT-prolonging drugs or strong CYP3A4 inhibitors such as ketoconazole or erythromycin.

It is also contraindicated where stimulating stomach movement is dangerous: gastrointestinal bleeding, mechanical obstruction or perforation. It should not be used in prolactin-secreting pituitary tumour (prolactinoma). Use in pregnancy, infants and the elderly requires specific medical judgement rather than routine use.

Pregnancy: Data on domperidone in pregnancy are limited. It should be used only when a doctor judges the expected benefit to outweigh potential risk, at the lowest dose for the shortest time. Safer-established measures for pregnancy nausea are usually preferred first.

Lactation: Small amounts pass into breast milk. Although domperidone raises prolactin, it is not an approved or routine way to increase milk supply, and infant heart-rhythm risk cannot be fully excluded. Breastfeeding mothers should use it only on medical advice, especially if the baby was premature or has heart problems.

Store as printed on the pack and keep out of the reach of children.