Clobetasol Propionate + Neomycin Sulphate + Nystatin

Clobetasol Propionate + Neomycin Sulphate + Nystatin is a potent topical corticosteroid with antibiotic and antifungal medicine available in Bangladesh under many brand names. Below are its uses, dosage, side effects and precautions — and all brands with their current prices.

• Short-term treatment of steroid-responsive inflammatory skin conditions complicated by, or at risk of, bacterial infection and Candida fungal infection, when prescribed by a clinician.
• Examples may include infected eczema or dermatitis where this combination is considered appropriate by the prescriber.

Adults: apply a thin layer to the affected skin as directed by the doctor, usually once or twice daily for the shortest possible time. Do not cover with an airtight dressing, apply to large areas, or continue beyond the prescribed duration unless advised. Dose and duration depend on the site, severity, age, and response, so follow the prescribing doctor’s instructions.

• Common: burning, stinging, itching, dryness, irritation, redness, or rash at the application site.
• Skin thinning, stretch marks, easy bruising, changes in skin colour, increased hair growth, acne-like eruptions, or worsening of infection, especially with prolonged use.
• Allergic contact dermatitis, particularly due to neomycin, may cause worsening redness, swelling, itching, or oozing.
• Serious but uncommon: adrenal suppression or other systemic steroid effects if used on large areas, under occlusion, for long periods, or in children.
• Rare risk of hearing or kidney toxicity from neomycin if absorbed through damaged skin or large areas.

Use with caution on thin skin, damaged skin, large areas, in children, elderly patients, or people with poor circulation, diabetes, or a history of allergy to neomycin or other aminoglycoside antibiotics. Avoid the eyes, inside the mouth, mucous membranes, face, groin, and underarms unless specifically prescribed. Stop and seek medical advice if irritation, allergy, spreading infection, or lack of improvement occurs. Use under a registered doctor's or pharmacist's guidance.

• Other topical corticosteroids or irritating skin products may increase local side effects.
• Use with occlusive dressings can increase absorption of clobetasol and neomycin and raise the risk of adverse effects.
• If applied to large areas or broken skin, caution is needed with other aminoglycoside antibiotics or medicines that may affect the kidneys or hearing.
• No important food interaction is expected with normal topical use.

• Known hypersensitivity to clobetasol, neomycin, nystatin, aminoglycoside antibiotics, or any component of the product.
• Untreated bacterial, fungal, viral, or parasitic skin infections not appropriate for this combination.
• Viral skin conditions such as herpes simplex, chickenpox, or shingles at the application site.
• Acne, rosacea, perioral dermatitis, or itching around the anus or genitals unless specifically directed by a doctor.
• Use in the ear if the eardrum is perforated, because neomycin may be harmful to hearing.

During pregnancy or breastfeeding, use only if clearly needed and prescribed. Avoid prolonged use, large areas, or occlusive dressings. If breastfeeding, do not apply to the nipple or breast area where the infant may ingest it; wash hands after application and seek medical advice.

Store at room temperature, away from excessive heat, direct sunlight, and moisture. Keep the tube tightly closed and out of the reach of children. Do not freeze, and do not use after the expiry date.