Cefuroxime + Clavulanic Acid

Cefuroxime + Clavulanic Acid is a cephalosporin antibiotic with beta-lactamase inhibitor medicine. It is available in Bangladesh under many brand names. Below are its uses, side effects and precautions, and every brand with its current price.

• Treatment of infections caused by susceptible bacteria where oral cefuroxime therapy is appropriate and beta-lactamase-producing organisms may be involved.
• Upper and lower respiratory tract infections, including sinusitis, tonsillitis/pharyngitis, acute exacerbation of chronic bronchitis, and community-acquired pneumonia when clinically suitable.
• Ear infections such as acute otitis media.
• Uncomplicated urinary tract infections caused by susceptible organisms.
• Skin and soft-tissue infections caused by susceptible organisms.
• Use should be guided by local antibiotic policy, culture and sensitivity results when available, and the prescriber’s clinical judgement.

• Common side effects may include nausea, vomiting, diarrhoea, abdominal pain, indigestion, headache, dizziness, and rash.
• Antibiotics may cause oral or vaginal fungal overgrowth, especially with prolonged use.
• Serious but uncommon effects include severe allergic reactions, swelling of the face or throat, breathing difficulty, severe skin reactions, persistent or bloody diarrhoea suggesting antibiotic-associated colitis, liver problems such as jaundice or dark urine, and unusual bruising or bleeding.
• Seek urgent medical help if signs of severe allergy, severe diarrhoea, or jaundice occur.

Use Cefuroxime + Clavulanic Acid carefully in people with a history of allergy to penicillins, cephalosporins, or other beta-lactam antibiotics; kidney impairment; liver disease or previous jaundice related to clavulanic acid; gastrointestinal disease such as colitis; or recurrent diarrhoea with antibiotics. It should be used only for bacterial infections and the full prescribed course should be completed unless a doctor advises otherwise. Use this medicine under the guidance of a registered doctor or pharmacist.

• Probenecid can increase blood levels of cefuroxime and may raise the risk of side effects.
• Medicines that reduce stomach acidity, such as antacids, H2 blockers, or proton pump inhibitors, may reduce absorption of cefuroxime axetil; ask a pharmacist or doctor how to time doses.
• Warfarin and other oral anticoagulants may have an increased risk of altered clotting results; INR monitoring may be needed.
• Oral live typhoid vaccine may be less effective during antibiotic treatment; vaccination timing should be discussed with a healthcare professional.
• Food improves absorption of cefuroxime axetil, so tablets or suspension are generally taken after meals unless the prescriber advises otherwise.

• Known hypersensitivity to cefuroxime, clavulanic acid, cephalosporins, or any component of the formulation.
• History of a severe immediate allergic reaction, such as anaphylaxis, to penicillins, cephalosporins, carbapenems, or other beta-lactam antibiotics.
• History of cholestatic jaundice or significant liver dysfunction associated with clavulanic acid-containing antibiotics.

Cefuroxime has been used in pregnancy when an antibiotic is clearly needed, but any antibiotic during pregnancy should be taken only on a doctor’s advice. Cefuroxime and small amounts of related beta-lactam medicines can pass into breast milk; breastfeeding is usually possible when prescribed, but the infant should be observed for diarrhoea, rash, or thrush. Pregnant or breastfeeding patients should consult a registered doctor before use.

Store tablets in a cool, dry place away from heat, moisture, and direct sunlight, and keep out of reach of children. For powder for suspension, follow the label instructions for reconstitution and storage after mixing; many suspensions require refrigeration and have a limited usable period after preparation. Do not use after the expiry date or if the product looks or smells abnormal.