Vasopin 5 mg + 25 mg Tablet

Vasopin 5 mg + 25 mg Tablet contains amlodipine, a calcium channel blocker, and atenolol, a beta-blocker. It is used to manage high blood pressure and may also be prescribed for certain patients with angina as advised by a doctor.

Vasopin 5 mg + 25 mg tablet is a fixed-dose combination medicine from Silva Pharmaceuticals Ltd. containing Amlodipine + Atenolol. It is used to treat high blood pressure and angina when a single medicine is not enough to reach the target.

The two ingredients work in complementary ways. Amlodipine, a calcium channel blocker, relaxes and widens the blood vessels so blood flows with less resistance. Atenolol, a beta-blocker, slows the heart rate and reduces the force of each beat so the heart works less hard. Together they control blood pressure more effectively than either alone, and each can offset the other's side effects, such as ankle swelling or fast pulse.

• High blood pressure (hypertension) not adequately controlled by a single medicine
• Angina pectoris — effort-related chest pain
• Patients who need both a calcium channel blocker and a beta-blocker in one convenient tablet

ChamberBD shows dosing only from the approved product label, with its source named, and no label is on file for Vasopin 5 mg + 25 mg Tablet. Use the dose your doctor prescribed and the instructions in the pack leaflet.

Possible side effects include:

• Ankle or foot swelling (from amlodipine — often less than with amlodipine alone)
• Slow pulse, tiredness, weakness (from atenolol)
• Dizziness, light-headedness, headache
• Flushing, palpitations
• Cold hands and feet
• Sleep disturbance, vivid dreams
• Stomach upset, nausea
• Seek medical help for fainting, very slow pulse, marked breathlessness or severe swelling

• Monitor blood pressure and pulse regularly; keep a record for your doctor.
• Tell your doctor if you have asthma, COPD, diabetes, heart failure, liver or kidney disease, or circulation problems.
• Diabetics: the atenolol component can mask the warning signs of low blood sugar — check sugar levels more often.
• May cause dizziness or tiredness — judge your response before driving.
• Rise slowly from sitting or lying down.
• Inform your doctor or dentist before surgery or anaesthesia.
• Report ankle swelling that is severe or one-sided (one-sided swelling needs urgent assessment).

• Verapamil, diltiazem: with the beta-blocker component, risk of dangerously slow heart rate — avoid unless closely supervised
• Other blood pressure medicines: additive lowering of pressure
• Digoxin, amiodarone: further slowing of the heart
• Insulin and diabetes medicines: masked hypoglycaemia warning signs
• NSAID painkillers: may blunt the antihypertensive effect
• Simvastatin (high dose): amlodipine raises simvastatin levels — dose limits apply
• Clonidine: careful sequence needed when stopping
• Grapefruit juice (large amounts): may increase amlodipine levels

• Allergy to amlodipine, atenolol, other dihydropyridines or beta-blockers
• Very slow heart rate, sick sinus syndrome or second/third-degree heart block without a pacemaker
• Cardiogenic shock, severe low blood pressure (systolic below about 90 mmHg)
• Uncontrolled heart failure
• Severe asthma or history of severe bronchospasm
• Untreated phaeochromocytoma
• Severe aortic stenosis

Pregnancy: This combination is generally avoided in pregnancy. The atenolol component has been linked to slower growth of the baby, so doctors usually switch to pregnancy-safe alternatives such as labetalol or methyldopa. Tell your doctor immediately if you are or plan to become pregnant.

Lactation: Atenolol passes into breast milk in significant amounts and may slow the baby's heart; amlodipine also passes in small amounts. This combination is usually avoided during breastfeeding — ask your doctor for a safer option.

Store below 30°C in a cool, dry place away from light and moisture. Keep in the original pack and out of the reach of children. Do not use after the expiry date.